Aox1 ELISA Kit for Mouse(Mus musculus) | EIAab.comAox1 ELISA Kit for Mouse(Mus musculus)

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Aox1 (Gene name),

Aldehyde oxidase 1 (Protein name ), AOXA_MOUSE from NCBI database.

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General Annotation

Antigen Annotation

Predicted Eptitope

Vaild Sequence

Related Databases

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Gene name:

Aox1(Ao;Ro);

Protein name:

Aldehyde oxidase 1;

Alternative:

Retinal oxidase;1.17.3.-;Azaheterocycle hydroxylase 1);

Organism:

Mouse (Mus musculus).

General Annotation

Sub Unit:

Homodimer.

Function:

Oxidase with broad substrate specificity, oxidizing aromatic azaheterocycles, such as N1-methylnicotinamide and N-methylphthalazinium, as well as aldehydes, such as benzaldehyde, retinal, pyridoxal, and vanillin. Plays a role in the metabolism of xenobiotics and drugs containing aromatic azaheterocyclic substituents. Participates in the bioactivation of prodrugs such as famciclovir, catalyzing the oxidation step from 6-deoxypenciclovir to penciclovir, which is a potent antiviral agent. Also plays a role in the reductive metabolism of the xenobiotic imidacloprid (IMI) via its nitroreduction to nitrosoguanidine (IMI-NNO) and aminoguanidine (IMI-NNH(2)). Is probably involved in the regulation of reactive oxygen species homeostasis. May be a prominent source of superoxide generation via the one-electron reduction of molecular oxygen. Also may catalyze nitric oxide (NO) production via the reduction of nitrite to NO with NADH or aldehyde as electron donor. May play a role in adipogenesis. Cannot use xanthine and hypoxanthine as substrate.

Subcellular Location:

Cytoplasm

Protein Attributes:

Sequence length:

1333

Sequence:

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1333:

LTPEKIRMAC | EDKFTKMIPR | DEPGSYVPCN | IPV

3D Structure:

N/A

Predicted Eptitope:

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Vaild Sequence:

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Related Databases

UniGene:

Mm.26787

Pfam:

PF01315

SMR:

O54754

KEGG:

mmu:11761

Uniprot:

O54754

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ELISA Kit for Mouse Aldehyde oxidase 1

Cat.:

E5988m

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Manual:

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96T

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ELISA Kit for Mouse Aldehyde oxidase 1

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ELISA Kit for Mouse Aldehyde oxidase 1

Cat.:

E5988r

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96T

ELISA Kit for Mouse Aldehyde oxidase 1

Cat.:

E5988b

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96T

ELISA Kit for Mouse Aldehyde oxidase 1

Cat.:

E5988h

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96T

CLIA Kit for Mouse Aldehyde oxidase 1

Cat.:

U5988r

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Packing:

96T

CLIA Kit for Mouse Aldehyde oxidase 1

Cat.:

U5988m

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MSDS:

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Packing:

96T

CLIA Kit for Mouse Aldehyde oxidase 1

Cat.:

U5988b

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MSDS:

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Packing:

96T

CLIA Kit for Mouse Aldehyde oxidase 1

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CLIA Kit for Mouse Aldehyde oxidase 1

Cat.:

U5988h

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96T

Polyclonal Antibody for Mouse Aldehyde oxidase 1

Cat.:

P5988Rb-m

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Packing:

40ug/0.2ml

Polyclonal Antibody for Mouse Aldehyde oxidase 1

Cat.:

P5988Rb-h

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Packing:

40ug/0.2ml

Polyclonal Antibody for Mouse Aldehyde oxidase 1

Monoclonal Antibody for Mouse Aldehyde oxidase 1

Protein for Mouse Aldehyde oxidase 1

R&D Technical Data

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Precision

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Recovery

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Linearity

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References

1.

"Molecular cloning of the cDNA coding for mouse aldehyde oxidase: tissue distribution and regulation in vivo by testosterone."
Kurosaki M. , Demontis S. , Barzago M.M. , Garattini E. , Terao M.
Biochem. J.341:71-80(1999) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA];SUBCELLULAR LOCATION;INDUCTION;TISSUE SPECIFICITY
strain: CD-1.
tissue: Liver.
2.

"Molecular cloning of retinal oxidase/aldehyde oxidase cDNAs from rabbit and mouse livers and functional expression of recombinant mouse retinal oxidase cDNA in Escherichia coli."
Huang D.-Y. , Furukawa A. , Ichikawa Y.
Arch. Biochem. Biophys.364:264-272(1999) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA];FUNCTION AS RETINAL OXIDASE;CATALYTIC ACTIVITY;BIOPHYSICOCHEMICAL PROPERTIES;HOMODIMER
strain: C57BL/6 X CBA.
tissue: Liver.
3.

"The mouse aldehyde oxidase gene: molecular cloning, chromosomal mapping and functional characterization of the 5'-flanking region."
Demontis S. , Kurosaki M. , Saccone S. , Salvatore M. , Garattini E. , Terao M.
Biochim. Biophys. Acta1489:207-222(1999) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA];DEVELOPMENTAL STAGE
strain: 129/Sv.
tissue: Thymus.
4.

"Selective localization of mouse aldehyde oxidase mRNA in the choroid plexus and motor neurons."
Bendotti C. , Prosperini E. , Kurosaki M. , Garattini E. , Terao M.
NeuroReport8:2343-2349(1997) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 561-746;TISSUE SPECIFICITY
strain: C57BL/6J.
tissue: Liver.
5.

"Small-interference RNA-mediated knock-down of aldehyde oxidase 1 in 3T3-L1 cells impairs adipogenesis and adiponectin release."
Weigert J. , Neumeier M. , Bauer S. , Mages W. , Schnitzbauer A.A. , Obed A. , Groeschl B. , Hartmann A. , Schaeffler A. , Aslanidis C. , Schoelmerich J. , Buechler C.
FEBS Lett.582:2965-2972(2008) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION IN ADIPOGENESIS;DEVELOPMENTAL STAGE;INDUCTION
6.

"Site directed mutagenesis of amino acid residues at the active site of mouse aldehyde oxidase AOX1."
Schumann S. , Terao M. , Garattini E. , Saggu M. , Lendzian F. , Hildebrandt P. , Leimkuhler S.
PLoS ONE4:E5348-E5348(2009) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION AS OXIDASE;CATALYTIC ACTIVITY;SUBSTRATE SPECIFICITY;HOMODIMER;KINETIC PARAMETERS;REACTION MECHANISM;ACTIVE SITE;MUTAGENESIS OF VAL-806; MET-884 AND GLU-1265
7.

"Structure and evolution of vertebrate aldehyde oxidases: from gene duplication to gene suppression."
Kurosaki M. , Bolis M. , Fratelli M. , Barzago M.M. , Pattini L. , Perretta G. , Terao M. , Garattini E.
Cell. Mol. Life Sci.70:1807-1830(2013) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: TISSUE SPECIFICITY;IDENTIFICATION OF PARALOGS
8.

"Aldehyde oxidase importance in vivo in xenobiotic metabolism: imidacloprid nitroreduction in mice."
Swenson T.L. , Casida J.E.
Toxicol. Sci.133:22-28(2013) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION IN XENOBIOTIC METABOLISM;TISSUE SPECIFICITY

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